It depends on how you use the car. If it's a show/specialty car that you drive only on special occasions and otherwise keep parked under cover, it should last a long time with regular coats of protective wax.
But, if it's stored outside and/or driven for regular errands and commutes, it will show the wear. Not as much in terms of the finish going flat (if you're waxing it regularly) but in terms of stone chips (cellulose\lacquer chips very easily compared to enamel and especially 2K paints.)
It also will stain easily, for example the case of a overflow at the fuel filler neck. Have a cloth handy to mop those up ASAP if that happens. Bird poop also has a much higher chance of etching the paint, and tree sap might be unremovable (some saps are such that anything strong enough to remove the sap also can remove cellulose paint.)
There are celluose clear coats - if your paint of choice is a metallic you may (probably) need a clear coat. If you did choose to use any other type of clear coat, you have to check with the manufacturer to see if it is compatible with cellulose - many 2K clears will wrinkle with cellulose underneath.
If you are going to drive the car regularly for normal errands, I'd look at a good enamel with a hardener (non-isocyanate based one.) Your shade could be custom mixed by a paint shop if you give them a good sample. Even with cellulose you still need a good charcoal filter mask rated for organic vapors. These aren't expensive.
Dave